Forskningsartikler

Abstract

Anne-S. Helvik, Büşra Nur Temür, Sverre Bergh, Kjerstin Tevik

Abstract

The underlying mechanisms of the neuropsychiatric syndrome delirium are still unknown, but neuroinflammation is a central hypothesis. Chitinase-3-like-protein-1 (YKL-40/CHI3L1) is considered a marker of neuroinflammation when measured in cerebrospinal fluid (CSF). The aim of this study was to examine concentrations of CSF YKL-40 in patients with and without delirium, to enhance the understanding of delirium pathophysiology. A total of 545 hip fracture patients were included from two similar cohorts. CSF samples were collected in conjunction with spinal anaesthesia for hip fracture surgery. The patients were screened for delirium both pre- and postoperatively. Those with delirium were further divided into subgroups based on whether they developed it before surgery (prevalent delirium) or after surgery (incident delirium). Among patients without delirium, those who met some, but not all diagnostic criteria, were classified as having subsyndromal delirium. Prefracture cognitive function was assessed, and American Society of Anaesthesiologists physical status score was included as a marker of comorbidity. In total, 257 (47%) of the patients developed delirium. These patients were older and had a higher prevalence of dementia and severe systemic diseases. Among the patients without dementia, those with delirium had higher median concentration of CSF YKL-40 compared with those without delirium (first cohort: 175 versus 132 ng/mL, P = 0.01, second cohort: 243 versus 174 ng/mL, P < 0.001). No association was found among the patients with dementia. The results remained consistent when adjusting for age and comorbidity. No difference in median CSF YKL-40 concentration was found between patients who had delirium at the time of surgery (prevalent delirium) and those who developed it afterwards (incident delirium). Our findings support the hypothesis of neuroinflammation as a mechanism for delirium in patients without dementia.

Thea Berntsen, Kaj Blennow, Henrik Zetterberg, Ingrid Fæhn Brekke, Mathias Nikolai Petersen Hella, Tom Tarjei Lian, Lene B Solberg, Christian Thomas Pollmann, Adi Karabeg, Olav Tobias Ødegaard, Marius Myrstad, Kristian Sydnes, Roy Bjørkholt Olsen, Torgeir Bruun Wyller, Leiv Otto Watne, Bjørn Erik Neerland

Key Features

HUNT4 70+ is a sub-cohort of persons aged ≥70 years in the fourth survey of the Trøndelag Health Study (HUNT), established to provide data for aging research.

This population-based sample consists of 9956 individuals from the original HUNT catchment area, included between August 2017 and February 2019. In addition, an urban sample of 1743 persons was included in Trondheim city during October 2018–June 2019.

HUNT4 70+ covers comprehensive aspects of aging health, including clinical examinations, performance-based tests of physical and cognitive function, questionnaires, and biological samples.

High participation rates among the old and frail were obtained by examination in private homes and nursing homes when needed (15% of the participants).

The data can be linked to all national registers in Norway, such as cause of death, prescription, health-care utilization, and diagnosis registries.

Data access requires approval from a Norwegian Research Ethics Committee before application to the HUNT Research Centre. Contact HUNT Research Centre for collaboration and more info (ntnu.edu/hunt).

Håvard K Skjellegrind, Pernille Thingstad, Linda Gjøra, Marit Kolberg, Grete Kjelvik, Linda Ernstsen, Tone N Fagerhaug, Arnulf Langhammer, Steinar Krokstad, Bjørn Olav Åsvold, Marit Næss & Geir Selbæk

Abstract

Background: Olfactory training (OT) has been linked to changes in olfactory function and structural modifications in the olfactory bulb (OB); however, the neuroplastic potential in the OB remains unclear. In this pilot study, we investigate how OT with different exposure lengths influences olfactory bulb volume (OBV) and olfactory function in individuals with normosmia.

Methodology: Seventy-seven normosmic individuals were assigned to either standard OT, extended OT, or a control group. The intervention groups performed OT for three months, sniffing four odours – eucalyptus, lavender, mint and lemon ※ for 10 seconds per bottle, twice daily, totalling either 40 seconds (standard OT) or 4 minutes (extended OT), while the control group did not perform any OT. OBV (manual segmentation of 3-Tesla magnetic resonance images) and olfactory function (Sniffin’ Sticks test) were assessed at baseline, post-intervention and at one-year follow-up.

Results: OBV increased significantly in both the standard and extended OT groups after the intervention and at follow-up, compared to controls. There were no differences between the training methods and no significant changes in olfactory function.

Conclusions: In normosmic individuals, OBV increased after both standard and extended OT, with no differences between training methods. The volume increase was evident at three-month assessment and persisted at one-year follow-up, indicating that neuroplastic changes induced by OT occur rapidly and may extend beyond the duration of the training itself, an effect not previously reported. However, the OBV changes were not accompanied by improve-ments in olfactory function.

I Torvik Heian, A-S Helvik, T A Myklebust, E M Berntsen, T Hummel, S Nordgard, M Bratt, W Moe Thorstensen

Abstract

Background
Older adults receiving psychiatric care are at greater risk of adverse events (AEs) than younger patients. This reflects broader vulnerabilities, including marginalization, complex health needs, and frequent transitions between care settings. It is therefore necessary to investigate AE risk in this population and to validate a previous version of the Global Trigger Tool – Psychiatry (GTT-P), originally developed for the general psychiatric population, for use with older psychiatric patients.ObjectiveTo apply the Norwegian version of GTT-P in psychiatric care for older adults, to identify the prevalence of AEs in this subpopulation.

Methods
A retrospective cohort study was conducted by reviewing medical records of 184 patients aged 65+ admitted to a psychiatric hospital between 2022 and 2023. All patients who did not opt out were included.

Results
AEs were identified in 10.9% of patients. Triggers related to compulsory treatment and medication significantly increased AE risk. No AEs occurred without associated triggers. Of the AEs identified, 63% were considered avoidable.

Conclusions
This study demonstrates the utility of GTT-P in detecting AEs in older psychiatric patients. Specific clinical triggers were significantly associated with AEs. Preventive strategies and improved care coordination are essential to reduce avoidable harm and enhance patient safety in psychiatric care.

Arne Okkenhaug, Eivind Aakhus, Guro F Giskeødegård, Bodil J Landstad, Ellen T Deilkås

Abstract:

Background: Depression in older adults is common in general practice, but the optimal approach for identification and treatment is not entirely clear.

Aim: To explore physicians’ experiences with a structured collaborative model involving joint consultations between patients, general practitioners (GPs), and geriatric psychiatrists for managing depression in adults aged 65 years and older.

Methods: Three focus group discussions were conducted with 13 physicians (10 GPs and 3 psychiatrists) who had participated in a structured collaboration model as part of a recent cluster randomized intervention study. Data were analyzed using Systematic Text Condensation.

Results: Five themes emerged: (1) diagnostic challenges; (2) perceived advantages; (3) feasibility; (4) concerns about overdiagnosis and overtreatment; and (5) suggested adjustments to the model. Somatic presentations often overshadowed depressive symptoms, particularly under GPs time constraints. Joint consultations strengthened the GP-patient relationship and enabled mutual learning. The presence of the GP was viewed as essential for patient engagement. The model addressed a treatment gap for GPs and was considered by psychiatrists to be highly cost-effective. All participants supported broader implementation in clinical practice.

Conclusion: The GPs’ enthusiasm for this collaborative approach indicates an unmet need in the treatment of older patients with depression. By strengthening both the doctor-patient relationship and interdisciplinary collaboration between GPs and psychiatrists in a cost-effective manner, the use of such joint consultations should be further investigated.

Lars Christian Kvalbein-Olsen, Eivind Aakhus, Ole Rikard Haavet & Erik L Werner

Abstract

The increasing presence of older immigrants in European societies has led to growing interest in how they and their families experience and manage care in ageing. This study aimed to explore the pattern of reflections and expectations of 2nd generation Turkish immigrants in Norway regarding family care. Qualitative design was employed in this study. The sample consisted of 18 2ndgeneration individuals of Turkish origin living in Norway. All participants lived in and around the same city in the middle part of Norway. Data was collected through individual face-to-face interviews conducted between November 2024 and January 2025. The transcripts were examined using reflexive thematic analysis. Four main themes were identified. 1) Cultural Background and Caregiving: Traditional Turkish Norms, 2) Intergenerational Care Expectations: Shifting Norms and Values, 3) Family Care Under the Same Roof: Wishes and Realities, and 4) Negotiating Family Care Responsibility. These findings demonstrate that cultural norms and caregiving, intergenerational care expectations, and family care practices are dynamically negotiated among 2nd generation Turkish immigrants. The findings indicate that while caregiving responsibilities are primarily framed in terms of love and moral obligation, economic, spatial, and emotional challenges significantly complicate this process.

Büşra Nur Temür, Nilgün Aksoy, Lillian Karlsen & Anne-Sofie Helvik

Article in press, 26. january 2026

Abstract:

Comprehensive mapping of key physical activity (PA) types, postures, and sleep among older adults is important for informing public health policies and interventions. This study aimed to describe the 24-h time distribution of key PA types, postures, and sleep in a population-based sample of community-dwelling older adults and explore whether age, sex, and educational level influenced this distribution. Participants 65 years and older from the fourth survey of the Trøndelag Health Study (HUNT4, 2017-19) with ≥ 1 day of complete accelerometer recording were included (n = 8,114). PA types (walking, running, cycling), postures (standing, sitting, lying (awake)), and sleep were derived from the accelerometer data using validated machine learning models. Survey-weighted regression models were applied to describe the 24-h time distribution of PA types, postures, and sleep by age, sex, and education. Participants spent 4.1 h standing (SD 85.3 min), 82.8 min (SD 40.3 min) walking, 0.2 min (SD 1.7 min) running, 4.6 min (SD 7.2 min) cycling, 9.2 h (SD 115.5 min) sitting, 2.1 h (SD 86.6 min) lying (awake), and 7.1 h (SD 50.4 min) sleeping per day. Time spent standing and walking decreased, while time spent sitting, lying (awake), and sleeping increased with higher age. Women spent more time standing and sleeping, and less time walking, sitting, and lying (awake) than men. Higher education was associated with more time standing and walking and less time sitting. This study provides novel insights into the distribution of 24-h movement behaviors among older adults and can serve as a benchmark for future research on key PA types, postures, sleep, and their interactions.

Karen Sverdrup, Astrid Ustad, Gro Gujord Tangen, Atle Kongsvold, Beatrix Vereijken, Bjørn Heine Strand, Geir Selbæk, Linda Ernstsen & Paul Jarle Mork