Forskningsartikler

Abstract

Background
Older adults receiving psychiatric care are at greater risk of adverse events (AEs) than younger patients. This reflects broader vulnerabilities, including marginalization, complex health needs, and frequent transitions between care settings. It is therefore necessary to investigate AE risk in this population and to validate a previous version of the Global Trigger Tool – Psychiatry (GTT-P), originally developed for the general psychiatric population, for use with older psychiatric patients.ObjectiveTo apply the Norwegian version of GTT-P in psychiatric care for older adults, to identify the prevalence of AEs in this subpopulation.

Methods
A retrospective cohort study was conducted by reviewing medical records of 184 patients aged 65+ admitted to a psychiatric hospital between 2022 and 2023. All patients who did not opt out were included.

Results
AEs were identified in 10.9% of patients. Triggers related to compulsory treatment and medication significantly increased AE risk. No AEs occurred without associated triggers. Of the AEs identified, 63% were considered avoidable.

Conclusions
This study demonstrates the utility of GTT-P in detecting AEs in older psychiatric patients. Specific clinical triggers were significantly associated with AEs. Preventive strategies and improved care coordination are essential to reduce avoidable harm and enhance patient safety in psychiatric care.

Arne Okkenhaug, Eivind Aakhus, Guro F Giskeødegård, Bodil J Landstad, Ellen T Deilkås

Abstract:

Background: Depression in older adults is common in general practice, but the optimal approach for identification and treatment is not entirely clear.

Aim: To explore physicians’ experiences with a structured collaborative model involving joint consultations between patients, general practitioners (GPs), and geriatric psychiatrists for managing depression in adults aged 65 years and older.

Methods: Three focus group discussions were conducted with 13 physicians (10 GPs and 3 psychiatrists) who had participated in a structured collaboration model as part of a recent cluster randomized intervention study. Data were analyzed using Systematic Text Condensation.

Results: Five themes emerged: (1) diagnostic challenges; (2) perceived advantages; (3) feasibility; (4) concerns about overdiagnosis and overtreatment; and (5) suggested adjustments to the model. Somatic presentations often overshadowed depressive symptoms, particularly under GPs time constraints. Joint consultations strengthened the GP-patient relationship and enabled mutual learning. The presence of the GP was viewed as essential for patient engagement. The model addressed a treatment gap for GPs and was considered by psychiatrists to be highly cost-effective. All participants supported broader implementation in clinical practice.

Conclusion: The GPs’ enthusiasm for this collaborative approach indicates an unmet need in the treatment of older patients with depression. By strengthening both the doctor-patient relationship and interdisciplinary collaboration between GPs and psychiatrists in a cost-effective manner, the use of such joint consultations should be further investigated.

Lars Christian Kvalbein-Olsen, Eivind Aakhus, Ole Rikard Haavet & Erik L Werner

Abstract:

Purpose:
Suicide rates are high among older adults, yet research on risk factors associated with suicide in this age group remain largely unexplored. This study aims to examine the relationship between suicide and sociodemographic characteristics among individuals aged 60 and older.

Methods:
We utilized data from Norwegian national registries, identifying individuals aged 60 and older who died by suicide between 2005 and 2019 (n = 2060, 70.7% males), and used a case-control design. To examine the relationships between suicide and sociodemographic factors, we used descriptive analyses and conditional multivariate logistic regression analyses, stratified by sex and age categories.

Results:
Among individuals aged 60 to 69, risk factors for suicide included receiving a disability pension (odds ratio (OR) = 2.79 males, OR = 7.71 females), having mixed income sources (OR = 1.79 males, OR = 3.70 females), living alone (OR = 2.49 males, OR = 2.46 females), and living in urban areas, which was associated with an increased risk for females (OR = 1.85). Among males, living alone was also a significant risk factor for suicide in the 70 to 79 age group (OR = 1.85), and those aged 80 and above (OR = 2.16). Living in rural areas reduced risk for females aged 80 and above (OR = 0.05).

Conclusion:
This first register-based study of suicide in older adults in Norway highlights that living arrangements, urbanization level, and income source are significant risk factors for suicide among older adults. Interventions to improve social connectedness, with a focus on the urban-rural divide, could potentially reduce suicide risk. Sex and age categories should be considered in future research and when implementing preventive measures.

Anna Torp Johansen, Sissel Marguerite Bélanger, Anne Reneflot, Erlend Hem, Eivind Aakhus, Carine Øien-Ødegaard, Kim Stene-Larsen & Cecilie Bhandari Hartberg

Abstract:

Objectives: The prevalence of clinically significant depressive symptoms (CSDS) in community-living older adults ≥70 years living at home in Norway has not been investigated for years. This study aimed to examine the prevalence and variables related to CSDS in older adults 70+, with a sub-analysis among the oldest (80+).

Methods: In the Trøndelag Health Study (HUNT), Norway, 8911 inhabitants comprising 47.1 % men (mean age in women 77, SD 5.6 and men 76.5, SD 5.3, range 70-102.7) completed the Depression subscale in the Hospital Anxiety and Depression Scale (HADS-D). Chi-square and multivariable logistic regression were used to test variables associated with CSDS.

Results: The prevalence of CSDS (HADS-D ≥ 8) was in the total sample 8.4 % among women and 11.5 % among men, while among the oldest (80+), the prevalence was 14.4 % and 16.6 %, respectively. Feeling lonely or perceiving health as poor was associated with CSDS. Reported impaired functioning was associated with CSDS than in those without such limitations in men, but not in women.

Conclusions: Men had a higher prevalence of CSDS than women in the total sample and among the oldest (80+). Loneliness and poor health are important variables associated with CSDS.

Heidi Emly Sivertsen, Gørill Haugan & Anne-Sofie Helvik

Abstract

Bernt Bratsberg, Jennifer R Harris, Vegard Skirbekk, Yaakov Stern, Asta Kristine Håberg, Geir Selbæk, Bjørn Heine Strand, Trine Holt Edwin

Abstract:

COVID-19 containment measures reduced older adults’ healthcare access, with uncertain long-term effects on cognitive, physical, and mental health. To investigate whether reductions in primary and specialist healthcare service use during the pandemic were associated with changes in cognitive, physical, and mental health in community-dwelling older adults, with attention to sex differences. Data from the Norwegian Trøndelag Health Study collected before (HUNT4 70 + , 2017-2019) and after the pandemic (HUNT AiT, 2021-2023) included 5387 participants (53% women) aged 70 + . Propensity score matching, accounting for baseline confounders, was used to examine associations between reduced healthcare service use and cognitive, physical, and mental health changes from pre- to post-pandemic. Reduced contact with general practitioners was associated with greater cognitive decline among women (MoCa-change – 0.32 [95% CI – 0.62, – 0.32]). No differences were observed in physical or mental health. Reductions in other primary care services (e.g., in-home nursing, practical assistance) were associated with greater decline in cognitive function (MoCa-change – 0.94 [- 1.53, – 0.36]), particularly among men (MoCa-change – 2.12 [- 3.13, – 1.11]). Men also had a decline in physical function (SPPB-change – 1.06 [- 1.79, – 0.33]). No differences in mental health were observed. Reductions in specialist healthcare services were unrelated to health changes in the overall sample but linked to improved physical function in women (SPPB-change 0.32 [0.11, 0.53]). Although associations between reduced healthcare service use during the pandemic and cognitive, physical, and mental health were limited, findings highlight the importance of sustaining access to primary care for older adults during public health crises.Trial registration The study is pre-registered at ClinicalTrials.gov 02.02.2021, with the identification number NCT04792086.

Tanja Louise Ibsen, Ekaterina Zotcheva, Sverre Bergh, Debby Gerritsen, Gill Livingston, Hilde Lurås, Svenn-Erik Mamelund, Anne Marie Mork Rokstad, Bjørn Heine Strand, Richard C Oude Voshaar, Geir Selbæk

Abstract:

Objectives: To investigate patterns and correlates of depression among Norwegian older adults (age 70+), 1995-2019, and estimate the number of older adults with depression by 2050.

Design: Population-based cross-sectional study.

Setting and participants: Three surveys of the Trøndelag Health Study (Norway): HUNT2 (1995-96), HUNT3 (2007-08), and HUNT4 (2017-19). 22,822 home dwellers aged 70 + who participated in at least one of the three surveys.

Methods: Depression was defined as scores ≥8 on the depression subscale of the Hospital Anxiety and Depression Scale. Covariates included sex, age, education, marital status, and reported loneliness. Depression prevalence (%) was standardized to the Norwegian population by age, sex, and education for years close to the initial HUNT survey year (1995, 2006, and 2016). Projection of the total number of individuals with depression in the coming decades were estimated. Predictors of depression were analyzed with logistic regression and the potential reduction in depression prevalence by reducing the prevalence of loneliness was estimated.

Results: Standardized depression prevalence decreased from 16.7% (HUNT2) to 14.9% (HUNT3), and 11.5% (HUNT4), and was highest among men, the oldest (85+), the lower-educated, and in earlier surveys (all p < 0.001). Living alone was also associated with higher depression prevalence, but only if loneliness was present. While depression rates are falling, we expect the number of depressed individuals to double by 2050 as the population ages.

Conclusion and implications: Depression rates among adults aged 70 + decreased by 50% from 1995 to 2019, but less so among the oldest old. The rates were highest among single older men. Despite decreasing prevalence, the number of depressed older adults will increase significantly in the future. Given the major individual and societal costs of depression, this trend is alarming for societies preparing for the challenges posed by population aging. This can, however, be addressed by addressing predictors of depression.

Maria Lage Barca, Eivind Aakhus, Ellen Melbye Langballe, Thomas Hansen, Ragnhild Holmberg Aunsmo, Geir Selbæk, Steinar Krokstad, Bjørn Heine Strand

Abstract

Introduction: Loneliness is postulated to be a risk factor for dementia. However, the findings are inconsistent, and long-term studies on this association remain scarce.

Methods: In all, 9389 participants self-reported loneliness in the Trøndelag Health Study (HUNT) in HUNT1 (1984-1986), HUNT2 (1995-1997), and/or HUNT3 (2006-2008) and underwent cognitive assessment in HUNT4 (2017-2019) at age 70 years or older. Logistic regression was employed to analyze the association between the course of loneliness and dementia, with those never lonely as a reference.

Results: In the fully adjusted model, the odds ratio (OR) for persistent loneliness was 1.47 (95% confidence interval [CI] 1.10, 1.95). This attenuated when adjusting for depression (OR 1.28, 95% CI 0.95, 1.72).

Discussion: Persistent loneliness from midlife into older age, as well as becoming lonely, were associated with increased odds of dementia, whereas transient loneliness in midlife was not. These findings underscore the importance of reducing loneliness.

Clinical trial registration: The study was registered with ClinicalTrials.gov (NCT04786561) and is available online .

Highlights: Persistent and incident loneliness was associated with a higher risk of dementia.Transient loneliness was not associated with a higher risk of dementia.Loneliness 11 years before to the cognitive assessment was associated with dementia.Reducing the sense of loneliness might reduce or delay the onset of dementia.

Ragnhild Holmberg Aunsmo, Bjørn Heine Strand, Sverre Bergh, Thomas Hansen, Mika Kivimäki, Sebastian Köhler, Steinar Krokstad, Ellen M Langballe, Gill Livingston, Fiona E Matthews, Geir Selbæk

Abstract: 

Background: The COVID-19 pandemic increased social isolation in older adults, promoting mental and cognitive decline. The impact of social media on these effects remains unclear.

Aim: To investigate the long-term association of social isolation with mental and cognitive health in older adults and whether social media use mitigated this association.

Method: Data from the Norwegian Trøndelag Health Study before (2017-2019), during (January 2021), and after the pandemic (2021-2023) were analysed (N = 4844, 53% women, mean age 80 years). Multi-adjusted mixed-effects linear regression estimated differences in changes in mental (CONOR-MHI) and cognitive (MoCA) health related to self-reported social isolation and social media use. Beta (β) represents differences in change in z-score of CONOR-MHI or MoCA.

Results: Social isolation was associated with a steeper decline in mental health than no social isolation (β = 0.07, 95% CI 0.01, 0.13) but was not associated with change in cognitive health. Daily social media use was not related to change in mental health, whereas it was associated with a less steep cognitive decline than no social media use (< 1 h: β = 0.13, 95% CI 0.05, 0.20; ≥ 1 h: β = 0.10, 95% CI 0.01, 0.15). Stratified by social isolation, daily social media use < 1 h was related to a less steep cognitive decline than no social media use in both isolated (β = 0.15, 95% CI 0.02, 0.28) and non-isolated individuals (β = 0.13, 95% CI 0.03, 0.22).

Conclusion: Individuals experiencing social isolation during the pandemic had a steeper decline in mental, but not cognitive health, compared to those not isolated. Social media use did not buffer the decline in mental health but was associated with less steep cognitive decline. The pandemic showed limits of relying solely on digital solutions for social contact.

Tanja Louise Ibsen, Ekaterina Zotcheva, Sverre Bergh, Debby Gerritsen, Gill Livingston, Hilde Lurås, Svenn-Erik Mamelund, Anne Marie Mork Rokstad, Bjørn Heine Strand, Pernille Thingstad, Richard C Oude Voshaar & Geir Selbæk