Biblioteket har samlet tips til artikler, bøker og nettsider som kan leses i forkant eller underveis under konferansen 6. desember 2023. Biblioteket har i stor grad lagt ut referanser til litteratur og kunnskap som er relevant for denne konferansen, og som er åpent tilgjengelig. Biblioteket prøver å skaffe de artiklene som ønskes, men som ikke ligger åpent ute. Ta gjerne kontakt med oss.
Aldring og helse er en nasjonal tjeneste for alle, og alle kan låne fra vår biblioteksamling. Dette gjør man enkelt via nett, over telefon eller ved å besøke biblioteket. Mer informasjon om tjenesten er på bibliotekets hjemmeside.
Tips til litteratur og kunnskap
Del A: Diagnostikk
09.20 – 09.40: Hva sier retningslinjen om diagnostikk per i dag, og hva trengs i fremtiden? Karin Persson
Helsedirektoratet. (2017). Nasjonal faglig retningslinje for demens. Utredning ved mistanke om demens og leges oppfølging etter diagnose https://www.helsedirektoratet.no/retningslinjer/demens/utredning-ved-mistanke-om-demens-og-leges-oppfolging-etter-diagnose
09.40 – 10.00: Biomarkører i CSF Tormod Fladby
Espenes R, Kirsebom BE, Eriksson C, Waterloo K, Hessen E, Johnsen SH, Selnes P, Fladby T. (2020). Amyloid Plaques and Symptoms of Depression Links to Medical Help-Seeking due to Subjective Cognitive Decline. J Alzheimers Dis. 75(3):879-890. https://doi.org/10.3233/JAD-190712.
Jansen IE, van der Lee SJ, Gomez-Fonseca D, de Rojas I, Dalmasso MC, Grenier-Boley B, (…) Fladby, T, (…) & van der Flier W. (2022). Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers. Acta Neuropathol. 144(5):821-842. https://doi.org/10.1007/s00401-022-02454-z.
Kim, M., Leonardsen, E., Rutherford, S., Selbæk, G., Persson, K., Steen, N.E., Smeland, O.B., Ueland, T., Richard, G., Beckmann, C.F., Marquand, A.F., Alzheimer’s Disease Neuroimaging Initiative (ADNI), Andreassen, O.A., Westlye, L.T., Wolfers, T. & Moberget, T. (2023). Mapping Cerebellar Anatomical Heterogeneity in Mental and Neurological Illnesses. bioRxiv
https://doi.org/10.1101/2023.11.18.567647
Lorentzen IM, Espenes J, Eliassen IV, Hessen E, Waterloo K, Nakling A, Gísladóttir B, Jarholm J, Fladby T, Kirsebom BE. (2023). Investigating the relationship between allocentric spatial working memory and biomarker status in preclinical and prodromal Alzheimer’s disease. Appl Neuropsychol Adult. 8:1-13. https://doi.org/10.1080/23279095.2023.2236262.
Røvang MS, Selnes P, MacIntosh BJ, Rasmus Groote I, Pålhaugen L, Sudre C, Fladby, T & Bjørnerud, A. (2023) Segmenting white matter hyperintensities on isotropic three-dimensional Fluid Attenuated Inversion Recovery magnetic resonance images: Assessing deep learning tools on a Norwegian imaging database. PLoS ONE 18(8): e0285683. https://doi.org/10.1371/journal.pone.0285683
Siafarikas N, Kirsebom BE, Srivastava DP, Eriksson CM, Auning E, Hessen E, Selbæk G, Blennow K, Aarsland D, Fladby T. (2021). Cerebrospinal fluid markers for synaptic function and Alzheimer type changes in late life depression. Sci Rep. 11(1):20375. https://doi.org/10.1038/s41598-021-99794-9.
10.00 – 10.20: Biomarkører i blod. Oskar Hansson
Brum, W. S., Cullen, N. C., Janelidze, S., Ashton, N. J., Zimmer, E. R., Therriault, J., Benedet, A. L., Rahmouni, N., Tissot, C., Stevenson, J., Servaes, S., Triana-Baltzer, G., Kolb, H. C., Palmqvist, S., Stomrud, E., Rosa-Neto, P., Blennow, K. & Hansson, O., (2023). A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases. Nature Aging. 3, 9, p. 1079-1090 12 p.
https://doi.org/10.1038/s43587-023-00471-5
Festari C, Massa F, Cotta Ramusino M, Gandolfo F, Nicolosi V, Orini S, Aarsland D, Agosta F, Babiloni C, Boada M, Borroni B, Cappa S, Dubois B, Frederiksen KS, Froelich L, Garibotto V, Georges J, Haliassos A, Hansson O, Jessen F, Kamondi A, Kessels RPC, Morbelli S, O’Brien JT, Otto M, Perret-Liaudet A, Pizzini FB, Ritchie CW, Scheltens P, Vandenbulcke M, Vanninen R, Verhey F, Vernooij MW, Yousry T, Van Der Flier WM, Nobili F, Frisoni GB. (2023). European consensus for the diagnosis of MCI and mild dementia: Preparatory phase. Alzheimers Dement. 19(5):1729-1741. https://doi.org/10.1002/alz.12798.
Hansson O, Edelmayer RM, Boxer AL, Carrillo MC, Mielke MM, Rabinovici GD, Salloway S, Sperling R, Zetterberg H, Teunissen CE. (2022). The Alzheimer’s Association appropriate use recommendations for blood biomarkers in Alzheimer’s disease. Alzheimers Dement. 18(12):2669-2686. https://doi.org/10.1002/alz.12756.
Leuzy A, Mattsson-Carlgren N, Palmqvist S, Janelidze S, Dage JL, Hansson O. (2022) Blood-based biomarkers for Alzheimer’s disease. EMBO Mol Med. 14(1):e14408. https://doi.org/10.15252/emmm.202114408.
Mattsson-Carlgren N, Collij LE, Stomrud E, Pichet Binette A, Ossenkoppele R, Smith R, Karlsson L, Lantero-Rodriguez J, Snellman A, Strandberg O, Palmqvist S, Ashton NJ, Blennow K, Janelidze S, Hansson O. (2023). Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies. JAMA Neurology. epub. https://doi.org/10.1001/jamaneurol.2023.4596.
(2023, 4 dec)
Short, M.I., Fohner, A.E., Skjellegrind, H.K., Beiser, A., Gonzales, M.M., Satizabal, C.L., Austin, T.R., Longstreth, W.T., Bis, J.C., Lopez, O., Hveem, K., Selbæk, G., Larson, M.G., Yang, Q., Aparicio, H.J., McGrath, E.R., Gerszten, R.E., DeCarli, C.S., Psaty, B.M., Vasan, R.S., Zare, H. & Seshadri, S. (2023). Proteome Network Analysis Identifies Potential Biomarkers for Brain Aging. Journal of Alzheimer’s Disease
https://doi.org/10.3233/JAD-230145
Tangen, G.G., Nilsson, M.H., Stomrud, E., Palmqvist, S. & Hansson, O. (2022). Spatial Navigation and Its Association With Biomarkers and Future Dementia in Memory Clinic Patients Without Dementia. Neurology 99 (19). https://doi.org/10.1212/WNL.0000000000201106
Verberk IMW, Misdorp EO, Koelewijn J, Ball AJ, Blennow K, Dage JL, Fandos N, Hansson O, Hirtz C, Janelidze S, Kang S, Kirmess K, Kindermans J, Lee R, Meyer MR, Shan D, Shaw LM, Waligorska T, West T, Zetterberg H, Edelmayer RM, Teunissen CE. (2022). Characterization of pre-analytical sample handling effects on a panel of Alzheimer’s disease-related blood-based biomarkers: Results from the Standardization of Alzheimer’s Blood Biomarkers (SABB) working group. Alzheimers Dement. 18(8):1484-1497. https://doi.org/10.1002/alz.12510.
10.40 – 11.00: Normal kognitiv aldring og tidlige symptomer ved demens. Peter Bekkhus-Wetterberg.
Bekkhus-Wetterberg, P., Brækhus, A., Müller, E.G. , Norvik, M.I., Winsnes, I.E. & Wyller, T.B. (2022). Primær progressiv afasi. Tidsskr Nor Legeforen. https://doi.org/10.4045/tidsskr.22.0100
Franzen S; European Consortium on Cross-Cultural Neuropsychology (ECCroN); Watermeyer TJ, Pomati S, Papma JM, Nielsen TR, Narme P, Mukadam N, Lozano-Ruiz Á, Ibanez-Casas I, Goudsmit M, Fasfous A, Daugherty JC, Canevelli M, Calia C, van den Berg E, Bekkhus-Wetterberg P.(2022). Cross-cultural neuropsychological assessment in Europe: Position statement of the European Consortium on Cross-Cultural Neuropsychology (ECCroN). Clin Neuropsychol. 36(3):546-557. https://doi.org/10.1080/13854046.2021.1981456.
Kroeger D, Vetrivelan R. (2023). To sleep or not to sleep – Effects on memory in normal aging and disease. Aging Brain.3:100068. https://doi.org/10.1016/j.nbas.2023.100068.
11.00 – 11.20: Digital kognitiv selvtesting. Hanneke Rhodius-Meester
Atkins AS, Kraus MS, Welch M, Yuan Z, Stevens H, Welsh-Bohmer KA, Keefe RSE. (2022). Remote self-administration of digital cognitive tests using the Brief Assessment of Cognition: Feasibility, reliability, and sensitivity to subjective cognitive decline. Front Psychiatry. 13:910896. https://doi.org/10.3389/fpsyt.2022.910896.
Franke Föyen L, Sennerstam V, Kontio E, Lekander M, Hedman-Lagerlöf E, Lindsäter E. (2023). Objective cognitive functioning in patients with stress-related disorders: a cross-sectional study using remote digital cognitive testing. BMC Psychiatry. 23(1):565. https://doi.org/10.1186/s12888-023-05048-5.
Scharre DW, Chang SI, Nagaraja HN, Wheeler NC, Kataki M. (2021). Self-Administered Gerocognitive Examination: longitudinal cohort testing for the early detection of dementia conversion. Alzheimers Res Ther. 13(1):192. https://doi.org/10.1186/s13195-021-00930-4.
van Gils AM, van de Beek M, van Unnik AAJM, Tolonen A, Handgraaf D, van Leeuwenstijn M, Lötjönen J, van der Flier WM, Lemstra A, Rhodius-Meester HFM.(2022). Optimizing cCOG, a Web-based tool, to detect dementia with Lewy Bodies. Alzheimers Dement (Amst). 14(1):e12379. https://doi.org/10.1002/dad2.12379 .
DEL B: Behandling
12.30 – 12.55 Legemiddelbehandling ved Alzheimers sykdom – status og fremtid. Anne-Brita Knapskog
Knapskog AB, Engedal K, Selbæk G, Øksengård AR. (2021). Alzheimers sykdom – diagnostikk og behandling [Alzheimer’s disease – diagnosis and treatment]. Tidsskr Nor Laegeforen. 141(7). Norwegian. https://doi.org/10.4045/tidsskr.20.0919.
Persson, K., Leonardsen, E.H., Edwin, T.H., Knapskog, A-B., Tangen, G.G., Selbæk, G., Wolfers, T., Westlye, L.T. & Engedal, K. (2023). Diagnostic accuracy of brain age prediction in a memory clinic population and comparison with clinically available volumetric measures. Scientific Reports vol 13, Article number: 14957. https://doi.org/10.1038/s41598-023-42354-0
Tangen G.G., Sverdrup, K., Taraldsen, K., Persson, K., Engedal, K., Bekkhus-Wetterberg, P., Knapskog, A.B. (2023). Mobility and associations with levels of cerebrospinal fluid amyloid β and tau in a memory clinic cohort. Front Aging Neurosci. https://doi.org/10.3389/fnagi.2023.1101306
van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, Kanekiyo M, Li D, Reyderman L, Cohen S, Froelich L, Katayama S, Sabbagh M, Vellas B, Watson D, Dhadda S, Irizarry M, Kramer LD, Iwatsubo T. (2023). Lecanemab in Early Alzheimer’s Disease. N Engl J Med. 388(1):9-21. https://doi.org/10.1056/NEJMoa2212948.
Nettside:
Universitetet i Oslo, Med.fak. (2022, 6.1). Ny metode for behandling av Alzheimers sykdom. https://www.med.uio.no/klinmed/forskning/aktuelt/aktuelle-saker/2022/ny-metode-for-behandling-av-alzheimer
12.55 – 13.20 Demens med lewylegemer og Parkinson demens – hva skjer innen diagnostikk og behandling? Dag Årsland
Abdelnour C, Gonzalez MC, Gibson LL, Poston KL, Ballard CG, Cummings JL, Aarsland D. (2023). Dementia with Lewy Bodies Drug Therapies in Clinical Trials: Systematic Review up to 2022. Neurol Ther. 12(3):727-749. https://doi.org/10.1007/s40120-023-00467-8.
Bellenguez, C. (…) Aarsland, D. (…) Fladby, T. (…) Saltvedt, I. (…) Sando, S.B. (…) Selbæk, G. (…) Ulstein, I. (…) & Lambert JC. (2022). New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nat Genet. 54(4):412-436. https://doi.org/10.1038/s41588-022-01024-z.
Brem AK, Kuruppu S, de Boer C, Muurling M, Diaz-Ponce A, Gove D, Curcic J, Pilotto A, Ng WF, Cummins N, Malzbender K, Nies VJM, Erdemli G, Graeber J, Narayan VA, Rochester L, Maetzler W, Aarsland D. (2023). Digital endpoints in clinical trials of Alzheimer’s disease and other neurodegenerative diseases: challenges and opportunities. Front Neurol. 14:1210974. Https://doi.org/10.3389/fneur.2023.1210974.
Dietrichs E, Alves G, Benjaminsen E, Johansen KK, Tysnes OB. (2023). Treatment of motor symptoms in Parkinson’s disease. Tidsskr Nor Laegeforen. 143(7). English, Norwegian. https://doi.org/10.4045/tidsskr.22.0804
Donaghy PC, Carrarini C, Ferreira D, Habich A, Aarsland D, Babiloni C, Bayram E, Kane JP, Lewis SJ, Pilotto A, Thomas AJ, Bonanni L; Alzheimer’s Association International Society to Advance Alzheimer’s. (2023). Research and Treatment Lewy Body Dementias Prodromal Working Group. Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis. Alzheimers Dement. 19(7):3186-3202. https://doi.org/ 10.1002/alz.13105
Gibson, L.L., Abdelnour, C., Chong, J., Ballard, C. & Aarsland, D.(2023). Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers. Current Opinion in Neurology 36(4):p 264-275. https://doi.org/10.1097/WCO.0000000000001173
DEL C: Implementering
14.00 – 14.20: Hvordan kan spesialisthelsetjenesten forberede seg på et økt antall personer med behov for utredning? Ingvild Saltvedt.
Helsedirektoratet. (2017). Nasjonal faglig retningslinje om demens. https://keff.no/uploads/Faktaark/Medisinske-diagnosertilstander/Demens.pdf
Medbøen IT, Persson K, Nåvik M, Totland TH, Bergh S, Treviño CS, Ulstein I, Engedal K, Knapskog AB, Brækhus A, Øksengård AR, Horndalsveen PO, Saltvedt I, Lyngroth AL, Ranhoff AH, Skrettingland DB, Naik M, Soares JZ, Johnsen B, Selbaek G. (2022). Cohort profile: the Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) – a national research and quality registry with a biomaterial collection. BMJ Open. 12(9):e058810. http://doi.org/10.1136/bmjopen-2021-058810.
Bok kan lånes i biblioteket:
Rønqvist, T.K.., Wagle, J., Wilsosn, K. (red.). 2020. Utvidet demensutredning. En håndbok. Forlaget aldring og helse – akademisk, 2020
14.20 – 14.40: Kan fastlegene og hukommelsesteamene utrede flere, tidligere og med høyere presisjon? Marte Kvittum Tangen, Mona Michelet.
Chang M, Michelet M, Skirbekk V, Langballe EM, Hopstock LA, Sund ER, Krokstad S, Strand BH. (2023). Trends in the use of home care services among Norwegians 70+ and projections towards 2050: The HUNT study 1995-2017. Scand J Caring Sci. 37(3):752-765. https://doi.org/10.1111/scs.13158.
Michelet M, Lund A, Strand BH, Engedal K, Selbaek G, Bergh S. (2020). Characteristics of patients assessed for cognitive decline in primary healthcare, compared to patients assessed in specialist healthcare. Scand J Prim Health Care. 38(2):107-116. https://doi.org/10.1080/02813432.2020.1753334
Røsvik J, Michelet M, Engedal K, Bergh S, Bieber A, Gonçalves-Pereira M, Portolani DM, Hopper L, Irving K, Jelley H, Kerpershoek L, Meyer G, Marques MJ, Sjølund BM, Sköldunger A, Stephan A, Verhey F, de Vugt M, Woods B, Wolfs C, Zanetti O, Selbæk G. (2021). Development of best practice recommendations to enhance access to and use of formal community care services for people with dementia in Europe: a Delphi process conducted by the Actifcare project. Aging Ment Health. 25(12):2298-2309. https://doi.org/10.1080/13607863.2020.1822286.
14.40 – 15.10: Hvordan kunstig intelligens kan bedre diagnostiske verktøy for demens – noen praktiske eksempler. Ole Andreassen, Hanneke Rhodius-Meester.
Javed AR, Khan HU, Alomari MKB, Sarwar MU, Asim M, Almadhor AS, Khan MZ. (2023). Toward explainable AI-empowered cognitive health assessment. Front Public Health.;11:1024195. https://doi.org/10.3389/fpubh.2023.1024195.
Lee J, Barnard LR, Jones DT. (2023). Artificial intelligence and the aging mind. Aging (Albany NY). 15(8):2815-2816. https://doi.org/10.18632/aging.204644.
Leonardsen EH, Peng H, Kaufmann T, Agartz I, Andreassen OA, Celius EG, Espeseth T, Harbo HF, Høgestøl EA, Lange AM, Marquand AF, Vidal-Piñeiro D, Roe JM, Selbæk G, Sørensen Ø, Smith SM, Westlye LT, Wolfers T, Wang Y. (2022). Deep neural networks learn general and clinically relevant representations of the ageing brain. Neuroimage. 256:119210. https://doi.org/10.1016/j.neuroimage.2022.119210
van Gils AM, Visser LN, Hendriksen HM, Georges J, Muller M, Bouwman FH, van der Flier WM, Rhodius-Meester HF. (2021). Assessing the Views of Professionals, Patients, and Care Partners Concerning the Use of Computer Tools in Memory Clinics: International Survey Study. JMIR Form Res. 5(12):e31053. https://doi.org/10.2196/31053
Vrahatis AG, Skolariki K, Krokidis MG, Lazaros K, Exarchos TP, Vlamos P. (2023). Revolutionizing the Early Detection of Alzheimer’s Disease through Non-Invasive Biomarkers: The Role of Artificial Intelligence and Deep Learning. Sensors (Basel). 23(9):4184. https://doi.org/10.3390/s23094184.
15.10 – 15.30: Etiske utfordringer ved tidlig diagnostikk. Bjørn Hofmann
Hofmann B. (2023). Addressing the paradox: Health expansion threatening sustainable healthcare. Eur J Intern Med,19, S0953-6205(23)00332-1. https://doi.org/10.1016/j.ejim.2023.09.012
Hofmann,B. (2021).The role of philosophy and ethics at the edges of medicine. Philos Ethics Humanit Med. 16(1):14. https://doi.org/10.1186/s13010-021-00114-w.
Hofmann B. (2022). Managing the moral expansion of medicine. BMC Med Ethics. 23(1):97. https://doi.org/10.1186/s12910-022-00836-2.
Hofmann B. (2022). Ethical issues with geographical variations in the provision of health care services. BMC Med Ethics. 23(1):127. https://doi.org/10.1186/s12910-022-00869-7.
Hofmann B. To Consent or Not to Consent to Screening, That Is the Question. (2023). Healthcare (Basel). 11(7):982. https://doi.org/10.3390/healthcare11070982.